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Predictions

Chicago White Sox Vs. Chicago Cubs Preview, Predictions, & Odds | May 17, 2025

Chicago White Sox vs. Chicago Cubs
May 16, 2025; Chicago, Illinois, USA; Chicago Cubs first base Michael Busch (29) is safe at home plate as Chicago White Sox catcher Matt Thaiss (29) makes a tag during the second inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

Chicago White Sox (14-31) vs. Chicago Cubs (26-19)

Game Details: Saturday May 17, 2025 @ 2:20 pm EST

Location: Wrigley Field in Chicago, Illinois

S. Burke (R) vs. M. Boyd (L)

Where to Watch: MLB.TV

The Chicago White Sox and Chicago Cubs square off in Game 2 of the Crosstown Classic. The Cubs showed why they are one of the best offenses in the major leagues, routing the White Sox 13-3 in the opening game of the series. Leadoff hitter Pete Crow-Armstrong hit six RBIs yesterday to lead the team. The White Sox will look to even up the series, sending Sean Burke to the mound. Can the White Sox slow down the Cubs’ offense?

Betting Odds

TeamSpreadTotal RunsMoney Line
Chicago White Sox vs. Cincinnati Reds Preview, Prediction & Odds | May 15, 2025+1.5 (+114)Over 10 (-112)+235
Chicago Cubs logo-1.5 (-135)Under 10 (-108)-290
** Odds Courtesy of DraftKings**

Apex Tale of The Tape

Chicago White Sox vs. Cincinnati Reds Preview, Prediction & Odds | May 15, 2025Team StatsChicago Cubs logo
3.39Runs/G5.55
.214BA.250
.289OBP.327
.324SLG.436
.613OPS.763
34HR64
35SB51
4.04ERA4.02
1.37WHIP1.30
7.52K/98.02
.979Fielding Percentage.985
3Saves10

Projected Starting Pitchers H2H

Sean BurkePlayer StatsMatthew Boyd
2-4W/L3-2
4.15ERA2.78
43.1IP45.1
1.41WHIP1.30
29K45
22BB13

Key Stats

Chicago White Sox

The Chicago White Sox looked like they would make it a game at the beginning of the opener. Third baseman Miguel Vargas smacked two home runs and was a perfect 4 for 4 at the plate. Unfortunately, that was all the offense the team could muster. Luis Robert continued his struggles at the plate. Over the past seven games, he is only slashing .133/.133/.321, and he went 0 for 4 today, making those numbers even worse.

Right-hander Sean Burke takes the mound looking to continue his strong month. In 16.1 innings pitched over three starts, he has only surrendered ten hits and allowed two earned runs. Burke’s biggest problem is control. He hasn’t been able to go deep into games because he gives a lot of free bases. In the past three starts, he has walked 11 batters. If he has any hope of slowing down this offense, he is going to have to stop giving free bases away.

Chicago Cubs

The Chicago Cubs found their offense in game one of the series. Crow-Armstrong was the story of the day, going 4 for 5 with six RBIs and a home run, but many other players had multi-hit games. Seiya Suzuki had been struggling at the plate but went 2 for 4 yesterday with a couple of RBIs. Look for him to continue breaking out of his slump against an inferior opponent.

The Cubs are sending out left-hander Matthew Boyd to the mound. Boyd hasn’t dominated this season but has been the beneficiary of an elite offense behind him. However, in his last start against the New York Mets, he went six innings, giving up six hits, two earned runs, and striking out eight. The White Sox lineup is much different than the Mets.

Chicago White Sox vs. Chicago Cubs Betting Trends

Chicago White Sox vs. Cincinnati Reds Preview, Prediction & Odds | May 15, 2025Betting StatsChicago Cubs logo
4-6W/L 105-5
24-21ATS23-22
20-22-3O/U25-16-4

Prediction

The Chicago Cubs’ lineup has too many weapons for the Chicago White Sox to handle. Burke struggles with walks, and I see the Cubs jumping out to an early lead in this one, cruising to a victory. Give me the Cubs spread and I’m taking the over as well.

Final Pick

Chicago Cubs -1.5 (-135) & Over 10 (-112)